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ImmunoGlobe is the first graphical representation of the immune interactome, and is comprised of 253 immune system components and 1112 unique immune interactions with detailed functional and characteristic annotations. Analysis of this network shows that it recapitulates known features of the human immune system and can be used uncover novel multi-step immune pathways, examine species-specific differences in immune processes, and predict the response of immune cells to stimuli. ImmunoGlobe is publicly available through a user-friendly interface at www.immunoglobe.org and can be downloaded as a computable graph and network table.
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The edge list and node attributes table were used to generate ImmunoGlobe, a graphical immune interaction network model (Fig. 2a). ImmunoGlobe was manually organized to group nodes according to function, with node type indicated by shape (Fig. 2b). Immune cells are at the top, organized according to the differentiation tree from a common hematopoietic stem cell [19]. Innate immune cells are on the left, and adaptive immune cells are on the right. Non-immune cells that interact with the immune system are collected in a column on the left. Cytokines are grouped together, separated into subgroups of interleukins, chemokines, and other cytokines. Immune effector molecules are grouped together and further clustered by subtype (e.g. Complement, reactive oxygen species). Antigens (foreign or pathogenic molecules that can stimulate an immune response) are shown at the bottom of the network. Antibody isotypes are shown on the right. Different edge types are represented by lines of different colors and styles, detailed in Fig. 2c. Edge types that are considered positive interactions (i.e., activate, recruit, or promote survival) are in green. Negative interactions (i.e., inhibit, kill) are in red. Secrete is in purple. Other edges (differentiate, polarize) are in grey. Definitions of the edge types can be found in Note S2. ImmunoGlobe thus provides a visual catalog of directional interactions between immune components and is available as an interactive network for download (File S1) and online at www.immunoglobe.org.
The Japanese Society for Immunology first published Karada wo Mamoru Meneki no Fushigi as part of its outreach efforts for the 2008 Day of Immunology. Recognising the value of such a resource in making immunology accessible to the public, particularly adolescents, EFIS translated the Japanese text to English and released Your Amazing Immune System - How it Protects Your Body in 2009. Since then, the book has been translated with EFIS support into 20 other languages, the versions of which may be downloaded from the links provided below.
Review of Medical Microbiology and Immunology 14th Edition by Warren Levinson pdf free download. This book is a concise review of the medically important aspects of microbiology and immunology. It covers both the basic and clinical aspects of bacteriology, virology, mycology, parasitology, and immunology. It also discusses important infectious diseases using an organ system approach. 041b061a72